• 1-methyl-2-amino-imidazol-4-one, 1-methylglycocyamidine, 1-methylhydantoin, 1-methylhydantoin-2-imide, 2-imino-1,5-dihydro-1-methyl-4H-imidazol-4-one, 2-amino-1,5-dihydro-1-methyl, 2-imino-1,5-dihydro-1-methyl-4H-imidazol-4-one, 2-imino-1-methyl-4-imidazolidinone, 2-imino-1-methylimidazolidin-4-one, 4H-imidazol-4-one,2-amino-1,5-dihydro-1-methyl, 45514-66-7, 60-27-5, 82016-55-5, AI3-15321, AIDS166904, C00791, CHEMBANK986, creatine monohydrate, creatinine, creatinine (VAN) (8CI), EINECS 200-466-7, heated creatinine, mineral oil, NISTC60275, NSC-8752 injections, NSC13123, substance X, ZINC00895382, ZINC00967189.

• It is claimed that krebiozen, originally called substance X, came from horses inoculated with Actinomyces bovis by Dr. Stevan Durovic. Durovic claimed that krebiozen had been useful in the treatment of spontaneous cancer, mainly in cats and dogs. It is unclear what kreboizin really contained; in some cases it was found to be creatine monohydrate and in other cases it contained mineral oil and l-methylhydantoin, a product of heating creatine monohydrate.
• Several studies have failed to show beneficial results from kreboizen. Reports published by the Krebiozen Foundation found improvement in cancer patients, but these results were disproven by the U.S. Food and Drug Administration (FDA) and the National Cancer Institute. Dr. Andrew Ivy (University of Illinois), Dr. Stevan Durovic, and Marko Durovic were brought to trial for violations of FDA regulations. There is currently no scientific proof that krebiozen is a viable treatment option for high blood pressure, cancer remission or any other condition.

• Bilateral pneumonectomy (surgical removal of lung), bladder cancer, cancer (breast, cervical), high blood pressure.

Adults (over 18 years old)

• There is no proven safe or effective dose for kreboizen in adults.

Children (under 18 years old)

• There is no proven safe or effective dose for kreboizen, and use in children is not recommended.

Allergies

• Avoid in individuals with a known allergy or hypersensitivity to creatine monohydrate.

Side Effects and Warnings

• There is insufficient evidence to support the use of krebiozen. Patients should be made aware of the existing treatment options for their specific conditions, particularly treatments with demonstrated efficacy. Pain and mild icterus (jaundice) have been reported. Avoid use in patients with cancer as only negative data has been published.

Pregnancy & Breastfeeding

• Kreboizen is not recommended in pregnant or breastfeeding women due to a lack of available scientific evidence.

Interactions with Drugs

• Insufficient available evidence.

Interactions with Herbs & Dietary Supplements

• Insufficient available evidence.

• This information is based on a systematic review of scientific literature edited and peer-reviewed by contributors to the Natural Standard Research Collaboration (www.naturalstandard.com).

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2. Anon. Unproven methods of cancer management. Krebiozen and carcalon. CA Cancer J Clin 1973;23(2):111-115.
3. Beck M. [Remedies and quackeries]. Acta Pharm Hung 1999;69(1):5-8.
4. Holland JF. The krebiozen story. Is cancer quackery dead? JAMA 1967;200(3):213-218.
5. Jallut O, Guex P, Barrelet L. [Unproven methods in oncology]. Schweiz Med Wochenschr 1984;114(36):1214-1220.
6. Janssen WF. Cancer quackery--the past in the present. Semin Oncol 1979;6(4):526-536.
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8. Stolinsky DC, Bateman JR. Recurrent masses at sites of prior Krebiozen (NSC-8752) injections. Cancer Chemother Rep 1974;58(2):249-250.